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| Pelin, Marco; Kilcoyne, Jane; Florio, Chiara; Hess, Philipp; Tubaro, Aurelia; Sosa, Silvio. |
| Background: Azaspiracids (AZAs) are marine toxins that are produced by Azadinium and Amphidoma dinoflagellates that can contaminate edible shellfish inducing a foodborne poisoning in humans, which is characterized by gastrointestinal symptoms. Among these, AZA1, -2, and -3 are regulated in the European Union, being the most important in terms of occurrence and toxicity. In vivo studies in mice showed that, in addition to gastrointestinal effects, AZA1 induces liver alterations that are visible as a swollen organ, with the presence of hepatocellular fat droplets and vacuoles. Hence, an in vitro study was carried out to investigate the effects of AZA1, -2, and -3 on liver cells, using human non-tumor IHH hepatocytes. Results: The exposure of IHH cells to... |
| Tipo: Text |
Palavras-chave: Azaspiracids; Hepatocytes; Mitochondrial activity; Mechanism of toxicity. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00494/60526/63989.pdf |
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| Noriega-González,J. E; Chirino,Y. I; Mata-Miranda,M. M; Vázquez-Zapién,G. J; Sánchez-Monroy,V. |
| Obesity has reached epidemic proportions, the World Health Organization (WHO) estimates that there are more than 1,000 million overweight adults world-wide. Furthermore, obesity is characterized as an overgrowth of white adipose tissue as a result of adipocyte hypertrophy and hyperplasia. Mitochondria is considered the source of energy within the adipocyte, since it contains the molecular machinery, and it is involved in a large number of metabolic pathways, besides the transformation of chemical energy into adenosine triphosphate. Mitochondria shortage and adipocyte dysfunction result in an excessive accumulation of triacylglycerol in the cytoplasm, which determines an imbalance between energy production and energy expenditure. Resveratrol (RSV) is a... |
| Tipo: Journal article |
Palavras-chave: Preadipocytes; Differentiated mature adipocyte; Mitochondrial activity; Resveratrol. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300044 |
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